Dysmagenesemia in critically ill patients: prevalence and nature of magnesium disorder.
Keywords:Dysmagnesemia hypomagnesemia, hypermagnesemia, intensive care unit, critical illness.
Background: Magnesium, ranks on number four for its abundancy in the body. It is known as “the forgotten electrolyte” in the literature. It is second most abundant intracellular cation. Altered magnesium level is frequently encountered electrolyte imbalance in critically ill patients. It increases ICU related morbidity and mortality. Identification and prompt management of magnesium disorder helps in reducing ICU related mortality.
Material and methods: we performed a prospective interventional study in which we collected data from intensive care unit of liaquat national hospital. We included only those patients who were having critical illness. We then measured serum magnesium level in all patients and reported the findings.
Results: A total of 107 patients from the Medical ICU were included in this study .56 were females (52%) and 51(47.7%) were males. The mean age was 59.6 years. We found that 63.3 % of patients had deranged levels of magnesium. 47.7 % of patients had hypermagnesemia whereas 15.9% of patients had hypomagnesemia.
Conclusion: Dysmagenesemia is significantly common in critically ill patient.
Thongprayoon C, Cheungpasitporn W, Erickson SB. Admission hypomagnesemia linked to septic shock in patients with systemic inflammatory response syndrome. Renal failure. 2015;37(9):1518-21.
Workeneh BT, Uppal NN, Jhaveri KD, Rondon-Berrios H. Hypomagnesemia in the cancer patient. Kidney360. 2021 Jan 28;2(1):154.
Vink R, Nechifor M. Magnesium in the central nervous system.
Corbi G, Acanfora D, Iannuzzi GL, Longobardi G, Cacciatore F, Furgi G, Filippelli A, Rengo G, Leosco D, Ferrara N. Hypermagnesemia predicts mortality in elderly with congestive heart disease: relationship with laxative and antacid use. Rejuvenation Research. 2008 Feb 1;11(1):129-38.
Cheungpasitporn W, Thongprayoon C, Qian Q. Dysmagnesemia in hospitalized patients: prevalence and prognostic importance. InMayo Clinic Proceedings 2015 Aug 1 (Vol. 90, No. 8, pp. 1001-1010). Elsevier.
Upala S, Jaruvongvanich V, Wijarnpreecha K, Sanguankeo A. Hypomagnesemia and mortality in patients admitted to intensive care unit: a systematic review and meta-analysis. QJM: An Intern J Med. 2016;109(7):453-9.
Ünal M, Tamer L, Pata YS, Kilic S, Degˇirmenci U, Akbaş Y, et al. Serum levels of antioxidant vitamins, copper, zinc and magnesium in children with chronic rhinosinusitis. J Trace Elements Med Bio. 2004;18(2):189-92.
Siddiqui MU, Ali I, Zakariya M, Asghar SP, Ahmed MR, Ibrahim GH. Frequency OfHypomagnesemia In Patients With Uncontrolled Type Ii Diabetes Mellitus. PakArmed Forces Med J. 2016;66(6).845-50
Rasheed H, Elahi S, Ajaz H. Serum magnesium and atherogenic lipid fractions in type II diabetic patients of Lahore, Pakistan. Bio Trace Elem Res. 2012;148(2):165-9.
Khan KM, Naeem F, Iqbal R, Shah ZH, Ali R, Gilani N. To Determine the Frequency of Hypomagnesemia among patients with Acute Ischemic Stroke and to Study the Correlation of Serum Magnesium with Modified Rankin Scale After Acute Ischemic Stroke. Pak J Med Health Sci. 2015;9(4):1240-3.
Altura BM. Basic biochemistry and physiology of magnesium: a brief review. Magnesium and trace elements. 1991;10(2-4):167-71.
Laires, M.J., C.P. Monteiro, and M. Bicho, Role of cellular magnesium in health and human disease. Front Biosci, 2004. 9(262): p. 76.
Nasser R, Naffaa ME, Mashiach T, Azzam ZS, Braun E. The association between serum magnesium levels and community-acquired pneumonia 30-day mortality. BMC Infectious Diseases. 2018 Dec;18(1):1-7.
Wang H, Huang J, Jin X, Chen C, Zhang A, Wu Y, Chen C. Hypermagnesaemia, but Not Hypomagnesaemia, Is a Predictor of Inpatient Mortality in Critically Ill Children with Sepsis. Disease Markers. 2022 Jan 27;2022.
Malinowska J, Małecka-Giełdowska M, Olga C. Dysmagnesemia Is the Most Common Disturbance of the Calcium–Magnesium–Phosphorous Balance among Older Hospitalized People in Warsaw. Nutrients 2021, 13, 3395.
Wong, E.T., et al., A high prevalence of hypomagnesemia and hypermagnesemia in hospitalized patients. American journal of clinical pathology, 1983. 79(3): p. 348-352.
Hashizume, N. and M. Mori, An analysis of hypermagnesemia and hypomagnesemia. Japanese journal of medicine, 1990. 29(4): p. 368-372.
Bideau, R., R. Valdes Jr, and R.J. Elin, Acute hypermagnesemia and respiratory arrest following infusion of MgSO4 for tocolysis. Clinica chimica acta, 1999. 285(1-2): p. 191-193.
Pham, P.-C.T., et al., Hypomagnesemia: a clinical perspective. International journal of nephrology and renovascular disease. 7: p. 219.
Williams, R.J.P., Tilden Lecture. The biochemistry of sodium, potassium, magnesium, and calcium. Quarterly Reviews, Chemical Society, 1970. 24(3): p. 331-365.
Kolte, D., et al., Role of magnesium in cardiovascular diseases. Cardiology in review. 22(4): p. 182-192.
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