Successful Treatment of Acute Kidney Injury on Chronic Kidney Disease Due to Tubulointerstitial Nephritis and Acute Tubular Necrosis With Steroids and Mycophenolate Mofetil: A Case Report
DOI:
https://doi.org/10.53778/pjkd94328Keywords:
Tubulointerstitial nephritis, acute kidney injury, acute tubular injury, steroids, mycophenolate mofetilAbstract
Acute tubulointerstitial nephritis causes interstitial inflammation and tubular injury leading to acute kidney injury which can present as rapid decline in renal function. Early diagnosis and prompt treatment is essential. After taking informed consent from our patient we present a case report where a patient with chronic kidney disease presented with rapid decline of renal function. Furthermore, renal biopsy revealed the diagnosis of tubulointerstitial nephritis. She was later started on steroids and mycophenolate mofetil, to which she responded adequately. From this case we conclude that steroids and mycophenolate mofetil are helpful in treatment in acute tubulointerstitial nephritis.
References
(1) Praga M, González E. Acute interstitial nephritis. Kidney international. 2010 Jun 1;77(11):956-61.
(2) Rossert JA. Acute interstitial nephritis. Comprehensive clinical nephrology. 2000.
(3) Fogo AB, Lusco MA, Najafian B, Alpers CE. AJKD atlas of renal pathology: acute interstitial nephritis. American Journal of Kidney Diseases. 2016 Jun 1;67(6):e35-6.
(4) Sahutoglu T, Perazella MA. Update on acute tubulointerstitial nephritis: clinical features, immunologic insights, and diagnostic and treatment approaches. Kidney International Reports. 2025 Apr 1;10(6):1643.
(5) Allison AC, Eugui EM. Mycophenolate mofetil and its mechanisms of action. Immunopharmacology. 2000 May 1;47(2-3):85-118.
(6) González E, Gutiérrez E, Galeano C, Chevia C, de Sequera P, Bernis C, Parra EG, Delgado R, Sanz M, Ortiz M, Goicoechea M. Early steroid treatment improves the recovery of renal function in patients with drug-induced acute interstitial nephritis. Kidney international. 2008 Apr 2;73(8):940-6.
(7) Handa SP. Drug-induced acute interstitial nephritis: report of 10 cases. CMAJ: Canadian Medical Association Journal. 1986 Dec 1;135(11):1278.
(8) Muriithi AK, Leung N, Valeri AM, Cornell LD, Sethi S, Fidler ME, Nasr SH. Biopsy-proven acute interstitial nephritis, 1993-2011: a case series. American Journal of Kidney Diseases. 2014 Oct 1;64(4):558-66.
(9) Allison AC. Mechanisms of action of mycophenolate mofetil. Lupus. 2005 Mar;14(3_suppl):2-8.
(10) Preddie DC, Markowitz GS, Radhakrishnan J, Nickolas TL, D’Agati VD, Schwimmer JA, Gardenswartz M, Rosen R, Appel GB. Mycophenolate mofetil for the treatment of interstitial nephritis. Clinical Journal of the American Society of Nephrology. 2006 Jul 1;1(4):718-22.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2026 DR IQRA AHMED, Merina Khan, DR SYED NAYER MAHMUD

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
